SHS Web Conf.
Volume 68, 20197th International Interdisciplinary Scientific Conference SOCIETY. HEALTH. WELFARE
|Number of page(s)||7|
|Section||Health: Public Health and Health Promotion|
|Published online||25 November 2019|
Smoking and alcohol abuse – predictive factors in oropharyngeal squamous cell carcinoma: A retrospective study
1 Rıga Stradinš University, Department of Otolaryngology, Riga, Latvia
2 Riga East Clinical University Hospital, Oncology Centre of Latvia, Department of Head and Neck Surgery, Riga, Latvia
3 Rıga Stradiņš University, Institute of Microbiology and Virology, Riga, Latvia
4 Rıga Stradiņš University, Institute of Anatomy and Anthropology, Riga, Latvia
Oropharynx is one of the most common localizations for malignant neoplasms in the head and neck region. HPV-positive OPSCCs are the most common subtypes in Western countries with tobacco and alcohol use, remaining the major risk factors for cancer development in this region. The study aims to address the significance of smoking and alcohol abuse in OPSCC cases and perform a survival analysis of the patients with OPSCC treated over a 10-year period in a single hospital in Latvia, correlating these data with patients' hazardous habits (smoking and alcohol abuse). Out of 247 patients, the majority were smokers (75.95%, n = 180), approximately one third were habitual drinkers (35.19%, n = 82) or were exposed to both aforementioned major risk factors (31.47%, n = 73). Kaplan-Meier survival analysis showed significantly better survival for the patients without the aforementioned hazardous habits. Cox regression analysis proved a higher early death rate when both factors (smoking and alcohol abuse) were present. It seems that smoking has a higher predictive value than alcohol abuse.
Key words: smoking and alcohol use / oropharyngeal squamous cell carcinoma (OPSCC) / oropharynx / pharyngeal cancer / hazardous habits
© The Authors, published by EDP Sciences, 2019
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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