SHS Web Conf.
Volume 144, 20222022 International Conference on Science and Technology Ethics and Human Future (STEHF 2022)
|Number of page(s)||5|
|Section||Research on Bioethics and Medical Science and Technology Ethics|
|Published online||26 August 2022|
Targets Related to Vasculogenic Mimicry in Breast Cancer
Wuhan University of Bioengineering
* Corresponding author Email: email@example.com
Vasculogenic mimicry (VM) is the release of angiogenic factors from tumor cells, leading to morphological changes, migration and proliferation of vascular endothelial cells, ultimately leading to neovascularization. The presence of VM has been identified in breast cancer, the formation of VM also gives breast cancer a poor prognosis such as drug resistance and metastasis. The authors focus on the role of the PI3K/Akt signaling pathway, hypoxia-inducible factorα(HIFα), the P38/MAPK signaling pathway, cyclooxygenase (COX2), the epithelial-mesenchymal transition (EMT) pathway, non-coding RNAs, and the tumor phenotype in the development of VM in breast cancer, thus offering new ideas for the future treatment of breast cancer.
© The Authors, published by EDP Sciences, 2022
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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