SHS Web Conf.
Volume 148, 2022The 2nd International Conference on Public Relations and Social Sciences (ICPRSS 2022)
|Number of page(s)||4|
|Section||Public Relations and Gender Equality Analysis|
|Published online||31 October 2022|
Exposure of PM2.5 Exacerbates COVID-19 In Vivo
San Marino High School, San Marino, 91108, United States
Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affects many tissues and organs, especially lung damage. The respiratory system related comorbidities can increase the COVID-19 clinical symptoms and cause more damages. Since high PM2.5 exposure decreases the respiratory system function, I hypothesize that PM2.5 can induce aggravated COVID-19 symptoms. I propose to construct the human angiotensin converting enzyme 2 (hACE2) knock in mice model to mimic COVID-19 patients. PM2.5 particulates will be delivered into the mice container in the aerosol form for consecutive 5 days ending on day -7 (Day 0 is the day of SARS-CoV-2 virus challenge). On day 21, we will sacrifice the mice and analyze the autopsy samples via ELISA, flow cytometry and histology assays and so forth, which determine the secretion level of inflammatory cytokines and characterize the function of related tissue or organs. It will be shown that pre-PM2.5 exposure induces more severe COVID-19 symptoms with highly activated inflammatory responses.
© The Authors, published by EDP Sciences, 2022
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