Work environment risk indicators for pharmacists in the preparation of extemporaneous medicines

Zenija Roja; Henrijs Kalkis; Agnese Melluma

doi:10.1051/shsconf/202213102006

All issues

Volume 131 (2022)

SHS Web Conf., 131 (2022) 02006

References

Open Access

Issue		SHS Web Conf. Volume 131, 2022 8^th International Multidisciplinary Research Conference SOCIETY. HEALTH. WELFARE


Article Number		02006
Number of page(s)		10
Section		Health
DOI		https://doi.org/10.1051/shsconf/202213102006
Published online		11 January 2022

J. Burch, Compounding Pharmacists Provide Customized Care. North Carolina Medical Journal 78(3), 191–194 (2017) [Google Scholar]
P. Staubach, S. Salzmann, A. Peveling-Oberhag. Extemporaneous formulations in Germany - relevance for everyday clinical practice. Journal der Deutschen-Dermatologischen Gesellschaft (Journal of the German Society of Dermatology) 16(5), 566–574 (2018) [Google Scholar]
A. Aquilina. The extemporaneous compounding of paediatric medicines at Mater Dei Hospital. Journal of the Malta College of Pharmacy Practice 19, 28–30 (2013) [Google Scholar]
D. Dubins, A. Laschuk, C. Ho. Extemporaneous Compounding in Pharmacy Practice. In: Encyclopedia of Pharmacy Practice and Clinical Pharmacy, 418–451 (2019) [Google Scholar]
O. Kiselova, B. Maurma, V. Šidlovska, J. Zvejnieks. The Extent of Extemporaneous Preparation and Regulatory Framework of Extemporaneous Compounding in Latvia. Medicina 55(9), 531 (2019) [Google Scholar]
B. Prince, J. Lundevall. A growing codependency: compounding pharmacy and safety. International journal of pharmaceutical compounding 17(6), 485–489 (2013) [Google Scholar]
K.W. Fent, S. Durgam, C. Mueller. Pharmaceutical Dust Exposure at Pharmacies Using Automatic Dispensing Machines: A Preliminary Study. Journal of Occupational and Environmental Hygiene 11(11), 695–705 (2014) [Google Scholar]
R. Inaba, A. Hioki, Y. Kondo, H. Nakamura, M. Nakamura. Suspended particle and drug ingredient concentrations in hospital dispensaries and implications for pharmacists’ working environments. Environmental Health and Preventive Medicine 21(2), 105–110 (2015b) [Google Scholar]
O.G. Bhusnure, R.B. Dongare, S.B. Gholve, P.S. Giram. Chemical hazards and safety management in pharmaceutical industry. Journal of Pharmacy Research 12(3), 357369 (2018) [Google Scholar]
R. Inaba, A. Hioki, Y. Kondo, H. Nakamura, M. Nakamura. Prevalence of subjective symptoms among hospital pharmacists and association with drug compounding practices. Industrial health 53(1), 100–108 (2015a) [Google Scholar]
E. Oddone, S. Negri, F. Morandi, M. Imbriani. Pharmaceutical Industries Air Quality. Comprehensive Analytical Chemistry 73, 589–621 (2016) [Google Scholar]
W. Ruhm, J. Breckow, G. Dietze, A. Friedl, R. Greinert, P. Jacob, S. Kistinger, R. Michel, W. Mueller, H. Otten, C. Streffer, W. Weiss. Dose limits for occupational exposure to ionising radiation and genotoxic carcinogens: a German perspective. Radiation and Environmental Biophysics 59(1), 9–27 (2020) [Google Scholar]
G. Brambilla, F. Mattioli, L. Robbiano, A. Martelli. Update of carcinogenicity studies in animals and humans of 535 marketed pharmaceuticals. Mutation Research/Reviews in Mutation Research 750(1), 1–51 (2012) [Google Scholar]
N.B. Hopf, C. Bolognesi, B. Danuser, P. Wild. Biological monitoring of workers exposed to carcinogens using the buccal micronucleus approach: A systematic review and meta-analysis. Mutation Research/Reviews in Mutation Research 781, 11–29 (2019) [Google Scholar]
NIOSH (National Institute for Occupational Safety and Health) List of Antineoplastic and Other Hazardous Drugs in Healthcare Settings. https://www.cdc.gov/niosh/docs/2016-161/pdfs/2016-161.pdf7id10.26616/NIOSHPUB2016161 (2016) [Google Scholar]
T.N. Hanvold, P. Kines, M. Nykänen, S. Thomée, K. Holte, J. Vuori, M. Worsted, K.B. Veiersted. Occupational safety and health among young workers in the Nordic countries: A systematic literature review. Safety and Health at Work 10(1), 3–20 (2018) [Google Scholar]
S.B. Marahatta, S. Gautam, G. Paudel, U. Yadav. Awareness of occupational hazards and associated factors among automobile repair artisans in Kathmandu Metropolitan City, Nepal. Indian Journal of Occupational and EnvironmentalMedicine 22(1), 49–53 (2018) [Google Scholar]
M. Apatsidou, I. Konstantopoulou, E. Foufa, K. Tsarouhas, P. Papalexis, R. Rezaee, D. Spandidos, D. Kouretas, C. Tsitsimpikou C. Safe use of chemicals by professionalusers and health care specialists. Biomedical Reports 8(2), 160–165 (2018) [Google Scholar]
R.J. Willey. International Symposium on Safety Science and Technology Understanding a safety data sheet (SDS) in regards to process safety. Procedia Engineering 45, 857–867 (2012) [Google Scholar]
K.W. Fent, S. Durgam, M. Methner. CDC (Center of Disease Control and Prevention). Evaluation of pharmaceutical dust exposure at an outpatient pharmacy, Available at https://www.cdc.gov/niosh/hhe/reports/pdfs/2010-0078-3177.pdf (2013) [Google Scholar]
M.S. Sharifzadeh, C.A. Damalas, G. Abdollahzadeh. Perceived usefulness of personal protective equipment in pesticide use predicts farmers’ willingness to use it. Science of The Total Environment 609, 517–523 (2017) [Google Scholar]
C. Champmartin, F. Clerc. Inhalable Dust Measurements as a First Approach to Assessing Occupational Exposure in the Pharmaceutical Industry. Journal of Occupational and Environmental Hygiene 11(2), 85–92 (2012) [Google Scholar]
C.C. Jung, P.C. Wu, C.H. Tseng, H.J. Su. Indoor air quality varies with ventilation types and working areas in hospitals. Building and Environment 85, 190–195 (2015) [Google Scholar]
C.Y. Hon, K. Teschke, W. Chu, P. Demers, S. Venners. Antineoplastic Drug Contamination of Surfaces Throughout the Hospital Medication System in Canadian Hospitals. Journal ofOccupational and Environmental Hygiene 10(7), 374–383 (2013) [Google Scholar]
C.Y. Hon, K. Teschke, W. Chu, P. Demers, S. Venners. Antineoplastic Drug Contamination on the Hands of Employees Working Throughout the Hospital Medication System. The Annals ofOccupational Hygiene 58(6), 761–770 (2014) [Google Scholar]

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[1] J. Burch, Compounding Pharmacists Provide Customized Care. North Carolina Medical Journal 78(3), 191–194 (2017) [Google Scholar]

[2] P. Staubach, S. Salzmann, A. Peveling-Oberhag. Extemporaneous formulations in Germany - relevance for everyday clinical practice. Journal der Deutschen-Dermatologischen Gesellschaft (Journal of the German Society of Dermatology) 16(5), 566–574 (2018) [Google Scholar]

[3] A. Aquilina. The extemporaneous compounding of paediatric medicines at Mater Dei Hospital. Journal of the Malta College of Pharmacy Practice 19, 28–30 (2013) [Google Scholar]

[4] D. Dubins, A. Laschuk, C. Ho. Extemporaneous Compounding in Pharmacy Practice. In: Encyclopedia of Pharmacy Practice and Clinical Pharmacy, 418–451 (2019) [Google Scholar]

[5] O. Kiselova, B. Maurma, V. Šidlovska, J. Zvejnieks. The Extent of Extemporaneous Preparation and Regulatory Framework of Extemporaneous Compounding in Latvia. Medicina 55(9), 531 (2019) [Google Scholar]

[6] B. Prince, J. Lundevall. A growing codependency: compounding pharmacy and safety. International journal of pharmaceutical compounding 17(6), 485–489 (2013) [Google Scholar]

[7] K.W. Fent, S. Durgam, C. Mueller. Pharmaceutical Dust Exposure at Pharmacies Using Automatic Dispensing Machines: A Preliminary Study. Journal of Occupational and Environmental Hygiene 11(11), 695–705 (2014) [Google Scholar]

[8] R. Inaba, A. Hioki, Y. Kondo, H. Nakamura, M. Nakamura. Suspended particle and drug ingredient concentrations in hospital dispensaries and implications for pharmacists’ working environments. Environmental Health and Preventive Medicine 21(2), 105–110 (2015b) [Google Scholar]

[9] O.G. Bhusnure, R.B. Dongare, S.B. Gholve, P.S. Giram. Chemical hazards and safety management in pharmaceutical industry. Journal of Pharmacy Research 12(3), 357369 (2018) [Google Scholar]

[10] R. Inaba, A. Hioki, Y. Kondo, H. Nakamura, M. Nakamura. Prevalence of subjective symptoms among hospital pharmacists and association with drug compounding practices. Industrial health 53(1), 100–108 (2015a) [Google Scholar]

[11] E. Oddone, S. Negri, F. Morandi, M. Imbriani. Pharmaceutical Industries Air Quality. Comprehensive Analytical Chemistry 73, 589–621 (2016) [Google Scholar]

[12] W. Ruhm, J. Breckow, G. Dietze, A. Friedl, R. Greinert, P. Jacob, S. Kistinger, R. Michel, W. Mueller, H. Otten, C. Streffer, W. Weiss. Dose limits for occupational exposure to ionising radiation and genotoxic carcinogens: a German perspective. Radiation and Environmental Biophysics 59(1), 9–27 (2020) [Google Scholar]

[13] G. Brambilla, F. Mattioli, L. Robbiano, A. Martelli. Update of carcinogenicity studies in animals and humans of 535 marketed pharmaceuticals. Mutation Research/Reviews in Mutation Research 750(1), 1–51 (2012) [Google Scholar]

[14] N.B. Hopf, C. Bolognesi, B. Danuser, P. Wild. Biological monitoring of workers exposed to carcinogens using the buccal micronucleus approach: A systematic review and meta-analysis. Mutation Research/Reviews in Mutation Research 781, 11–29 (2019) [Google Scholar]

[15] NIOSH (National Institute for Occupational Safety and Health) List of Antineoplastic and Other Hazardous Drugs in Healthcare Settings. https://www.cdc.gov/niosh/docs/2016-161/pdfs/2016-161.pdf7id10.26616/NIOSHPUB2016161 (2016) [Google Scholar]

[16] T.N. Hanvold, P. Kines, M. Nykänen, S. Thomée, K. Holte, J. Vuori, M. Worsted, K.B. Veiersted. Occupational safety and health among young workers in the Nordic countries: A systematic literature review. Safety and Health at Work 10(1), 3–20 (2018) [Google Scholar]

[17] S.B. Marahatta, S. Gautam, G. Paudel, U. Yadav. Awareness of occupational hazards and associated factors among automobile repair artisans in Kathmandu Metropolitan City, Nepal. Indian Journal of Occupational and EnvironmentalMedicine 22(1), 49–53 (2018) [Google Scholar]

[18] M. Apatsidou, I. Konstantopoulou, E. Foufa, K. Tsarouhas, P. Papalexis, R. Rezaee, D. Spandidos, D. Kouretas, C. Tsitsimpikou C. Safe use of chemicals by professionalusers and health care specialists. Biomedical Reports 8(2), 160–165 (2018) [Google Scholar]

[19] R.J. Willey. International Symposium on Safety Science and Technology Understanding a safety data sheet (SDS) in regards to process safety. Procedia Engineering 45, 857–867 (2012) [Google Scholar]

[20] K.W. Fent, S. Durgam, M. Methner. CDC (Center of Disease Control and Prevention). Evaluation of pharmaceutical dust exposure at an outpatient pharmacy, Available at https://www.cdc.gov/niosh/hhe/reports/pdfs/2010-0078-3177.pdf (2013) [Google Scholar]

[21] M.S. Sharifzadeh, C.A. Damalas, G. Abdollahzadeh. Perceived usefulness of personal protective equipment in pesticide use predicts farmers’ willingness to use it. Science of The Total Environment 609, 517–523 (2017) [Google Scholar]

[22] C. Champmartin, F. Clerc. Inhalable Dust Measurements as a First Approach to Assessing Occupational Exposure in the Pharmaceutical Industry. Journal of Occupational and Environmental Hygiene 11(2), 85–92 (2012) [Google Scholar]

[23] C.C. Jung, P.C. Wu, C.H. Tseng, H.J. Su. Indoor air quality varies with ventilation types and working areas in hospitals. Building and Environment 85, 190–195 (2015) [Google Scholar]

[24] C.Y. Hon, K. Teschke, W. Chu, P. Demers, S. Venners. Antineoplastic Drug Contamination of Surfaces Throughout the Hospital Medication System in Canadian Hospitals. Journal ofOccupational and Environmental Hygiene 10(7), 374–383 (2013) [Google Scholar]

[25] C.Y. Hon, K. Teschke, W. Chu, P. Demers, S. Venners. Antineoplastic Drug Contamination on the Hands of Employees Working Throughout the Hospital Medication System. The Annals ofOccupational Hygiene 58(6), 761–770 (2014) [Google Scholar]